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首页> 外文OA文献 >Evidence of Early B-Cell Dysregulation in Simian Immunodeficiency Virus Infection: Rapid Depletion of Naïve and Memory B-Cell Subsets with Delayed Reconstitution of the Naïve B-Cell Population▿
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Evidence of Early B-Cell Dysregulation in Simian Immunodeficiency Virus Infection: Rapid Depletion of Naïve and Memory B-Cell Subsets with Delayed Reconstitution of the Naïve B-Cell Population▿

机译：猿猴免疫缺陷病毒感染中早期B细胞调节异常的证据：幼稚和记忆B细胞亚群的快速消耗，幼稚B细胞群体的重建延迟▿

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Despite eliciting a robust antibody response in humans, several studies in human immunodeficiency virus (HIV)-infected patients have demonstrated the presence of B-cell deficiencies during the chronic stage of infection. While several explanations for the HIV-induced B-cell deficit have been proposed, a clear mechanistic understanding of this loss of B-cell functionality is not known. This study utilizes simian immunodeficiency virus (SIV) infection of rhesus macaques to assess B-cell population dynamics beginning at the acute phase and continuing through the chronic phase of infection. Flow cytometric assessment demonstrated a significant early depletion of both naïve and memory B-cell subsets in the peripheral blood, with differential kinetics for recovery of these populations. Furthermore, the altered numbers of naïve and memory B-cell subsets in these animals corresponded with increased B-cell activation and altered proliferation profiles during the acute phase of infection. Finally, all animals produced high titers of antibody, demonstrating that the measurement of virus-specific antibody responses was not an accurate reflection of alterations in the B-cell compartment. These data indicate that dynamic B-cell population changes in SIV-infected macaques arise very early after infection at the precise time when an effective adaptive immune response is needed.
机译：尽管在人体内引起了强烈的抗体反应，但对人类免疫缺陷病毒（HIV）感染的患者进行的几项研究表明，在慢性感染阶段存在B细胞缺陷。尽管已经提出了几种有关HIV引起的B细胞功能缺陷的解释，但对这种B细胞功能丧失的清晰机械理解尚不清楚。这项研究利用猕猴的猿猴免疫缺陷病毒（SIV）感染来评估从急性期开始一直持续到慢性期的B细胞种群动态。流式细胞仪评估显示，外周血中的幼稚B细胞亚群和记忆B细胞亚群的早期显着耗竭，并且动力学恢复这些人群。此外，这些动物中幼稚和记忆B细胞亚群数量的改变与感染急性期B细胞活化的增加和增殖模式的改变相对应。最后，所有动物都产生高滴度的抗体，这表明对病毒特异性抗体反应的测量不能准确反映B细胞区室的变化。这些数据表明感染SIV的猕猴中的动态B细胞种群变化在感染后的很早就出现了，需要精确的有效免疫应答。

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